Volume 15, Issue 2: 2025 - Article 206

Abstract
Canine transmissible venereal tumour is a round cell neoplasm that is spread by mating and physical transmission of the tumour cells. It is among the most prevalent tumours in dogs. The tumor is commonly observed on the external genitalia, although, there have been reports of internal organ metastases. When affected dogs mate, lick or sniff at the lesion, living tumour cells are spread from one dog to another. A three-year-old female mongrel dog was presented with complaints of discomfort, bloody visible mass on the vagina and frequent licking of the genitalia for over three months, with the history of staying out of the compound during the day, and with heavy tick infestation. The dog was diagnosed of transmissible venereal tumour (TVT) based on the history and clinical manifestation. Further histological and molecular diagnosis was not done, however, the history, vaginal location of the lesion, the gross appearance and the rapid recovery following vincristine sulphate therapy strongly supported the diagnosis of canine TVT. Chemotherapy was initiated by premedication with dexamethasone and sarolaner (Simparica®) tablets, followed by slow intravenous injection of vincristine sulphate, at a dose of 0.025 mg/kg once a week for four weeks. On the third week, the tumour growth regressed markedly and by the fourth week, there was no more manifestation of external genital bleeding. This treatment regimen significantly led to speedy recovery, and reduced treatment period with vincristine sulphate. Its application will possibly reduce the stress and cost of routine vincristine sulphate therapy for TVT, which commonly extends to six weeks.

Keywords: Dog; Transmissible venereal tumour (TVT); Chemotherapy; Vincristine sulphate; Dexamethasone; Sarolaner (Simparica®).

How to cite this article:
Olaoye MT (2025). Management of canine transmissible venereal tumour (TVT) with a combination of vincristine
sulphate, dexamethasone and sarolaner in a three-year-old mongrel dog: A case report. Journal of Veterinary and
Applied Sciences, 15(2): 1236 – 1241.

*Correspondence: E-mail:  mtmaky16@gmail.com      Phone: +2348030511117

Management of canine transmissible venereal tumour (TVT) with a combination of vincristine sulphate, dexamethasone and sarolaner in a three-year-old mongrel dog: A case report
Mariam T. Olaoye

Veterinary Services Department, Osun State Ministry of Agriculture and Food Security, Osogbo,
Osun State, Nigeria.

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